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The pain typically affects one side and may include tingling, numbness, or weakness in the affected leg

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465 The anterior cingulate cortex, essential for emotional pain processing, shows increased blood flow in patients with PDPN, a hyperperfusion state that normalizes following duloxetine treatment

In young children, iron deficiency also can lead to cognitive impairment, but it is not known if developing iron deficiency in adolescence would have the same effect